It is well known that TENS produces important clinical responses in different patients with pain and inflammation, but what are the mechanisms by which those responses are produced? Answering that question could help us to target and improve therapies. Dr. Sovak is working with different strains of neuronal cells, examining how TENS modulates the production and release of chemicals involved in pain and inflammation. He has discovered that TENS interrupts the normal behavior of cell membrane channels and ultimately suppresses the expression of certain genes responsible for inflammatory cytokine production.
