Mark Erwin, BA(Hons), DC, PhD

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Title: Associate Professor
Department: Research and Innovation
merwin@cmcc.ca

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Biography

Dr. W. Mark Erwin holds a Doctor of Chiropractic (DC) degree from CMCC, class of 1984, and a PhD obtained from the Institute of Medical Science, University of Toronto, 2004. He holds the academic rank of Assistant Professor within the Division of Orthopaedic Surgery at the University of Toronto and the Toronto Western Hospital. He is also cross-appointed to The Spine Program and is a scientist within the Toronto Western Research Institute and the Arthritis and Autoimmunity Research Centre (AARC) at the University Health Network. Dr. Erwin currently holds the position of Scientist in Disc Biology at the University of Toronto-a position jointly funded by the Canadian Chiropractic Research Foundation, the Musculoskeletal Health and Arthritis and Neuroscience programs at the Toronto Western Hospital. Dr. Erwin's principal area of interest is in development and regenerative medicine applications concerning the intervertebral disc.

Research Interests

regenerative medicine

Selected Publications

  1. Erwin WM, Hood KE. The Cellular and Molecular Biology of the Intervertebral Disc: A Clinician’s Primer. J Can Chiropr Assoc 2014;58(3) 246-257.
  2. Mehrkens A, Karim MZ, Kim S, Hilario R, Fehlings MG, Erwin WM. Canine notochordal cell-secreted factors protect murine and human nucleus pulposus cells from apoptosis by inhibition of activated caspase-9 and caspase-3/7. Evid Based Spine Care J. 2013 Oct;4(2):154-6.
  3. Erwin WM, Korpela AP, Jones RA. Chiropractors as Primary Spine Care Providers: precedents and essential measures  J Can Chiropr Assoc 2013; 57(4):285-291
  4. Rhee JM, Shamji MF, Erwin WM, Bransford RJ, Yoon ST, Smith JS, Kim HJ, Ely CG, Dettori JR, Patel AA, Kalsi-Ryan S. Nonoperative management of cervical myelopathy: a systematic review. Spine (Phila Pa 1976). 2013 Oct 15;38(22 Suppl 1):S55-67.
  5. Karadimas SK, Erwin WM, Ely CG, Dettori JR, Fehlings MG. Pathophysiology and natural history of cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2013 Oct 15;38(22 Suppl 1):S21-36.
  6. Kawchuck G, Bruno P, Busse JW, Bussieres A, Erwin WM, Passmore S, Srbely J. Knowledge Transfer within the Canadian Chiropractic Community.  Part 1: Understanding Evidence-Practice Gaps. J Can Chiropr Assoc 2013, 57(2); June 111-115
  7. Erwin WM. Biologically based therapy for the intervertebral disk: who is the patient? Global Spine J. 2013 Jun;3(3):193-200.
  8. Erwin WM. Canonical Wnt signaling and caveolae play a role in intervertebral disc degeneration; the continuing saga of the mysterious notochordal cell. Arthritis Res Ther. 2013 Mar 22;15(2):113.
  9. Hawryluk GW1, Spano S, Chew D, Wang S, Erwin M, Chamankhah M, Forgione N, Fehlings MG. An examination of the mechanisms by which neural precursors augment recovery following spinal cord injury: a key role for remyelination. Cell Transplant. 2014 Mar;23(3):365-80.
  10. Erwin WM, Islam D, Eftekarpour E, Inman RD, Karim MZ, Fehlings MG. Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair. Spine (Phila Pa 1976). 2013 Feb 1;38(3):211-6.
  11. Erwin WM, Fehlings MG. Intervertebral disc degeneration: genes hold the key. World Neurosurg. 2013 Nov;80(5):e131-3.
  12. Haldeman S, Kopansky-Giles D, Hurwitz EL, Hoy D, Erwin WM, Dagenais S, Kawchuk G, Strömqvist B, Walsh N. Advancements in the management of spine disorders. Best Pract Res Clin Rheumatol. 2012 Apr;26(2):263-80.
  13. Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW. N otochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration. Arthritis Res Ther. 2011;13(6):R215.
  14. Las Heras F, DaCosta RS, Pritzker KP, Haroon N, Netchev G, Tsui HW, Chiu B, Erwin WM, Tsui FW, Inman RD. Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice. Arthritis Res Ther. 2011;13(5):R163.
  15. Standaert CJ, Friedly J, Erwin WM, Lee MJ, Rechtine G, Henrikson NB, Norvell DC. Comparative effectiveness of exercise, acupuncture, and spinal manipulation for low back pain. Spine (Phila Pa 1976). 2011 Oct 1;36(21 Suppl):S120-30.
  16. Erwin WM. The enigma that is the nucleus pulposus cell: the search goes on. Arthritis Res Ther. 2010;12(3):11